Track record
Publications
Research by ReWrite scientists on iPSC reprogramming, genome editing and iPSC-derived disease models.
36 publications
These studies were carried out at the Stem Cell Institute Leuven (KU Leuven) by scientists who now work at ReWrite. All rights to this research belong to KU Leuven.
2023
- APEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells
Stem Cell Reviews and Reports, 19 (6), 2052-2072
- Automated Generation of hiPSC-Derived Hepatic Progeny by Cost-Efficient Compounds
Stem Cells
- CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity
Alzheimer's & Dementia, 19 (4), 1245-1259
- From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions
Acta Neuropathologica, 146 (2), 283-299
- Genetically Engineered Triple MAPT-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics
Cells, 12 (10), art. no. 1385
- Large-scale perfused tissues via synthetic 3D soft microfluidics
Nature Communications, 14 (1), art. no. 193
- Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis
Brain Behavior and Immunity, 109, 1-22
- The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation
Stem Cell Reports, 18 (1), 254-268
2022
- A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes
Journal of Proteome Research, 21 (3), 702-712
- DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy
Brain, 145 (12), 4368-4384
- HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity
Toxics, 10 (1), art. no. 1
- Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy
Stem Cell Reports, 17 (2), 352-368
- Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings
Biomedicines, 10 (2), art. no. 268
2021
- A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model
Biomaterials, 276, art. no. 121006
- Comparing in vitro human liver models to in vivo human liver using RNA-Seq
Archives of Toxicology, 95 (2), 573-589
- Fast and Efficient Generation of Isogenic Induced Pluripotent Stem Cell Lines Using Adenine Base Editing
CRISPR Journal, 4 (4), 502-518
- Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages
Archives of Toxicology, 95 (10), 3285-3302
- HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
EMBO Journal, 40 (7), art. no. e106177
- Patient-Specific Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells as a Model to Study Autosomal Recessive Hypercholesterolemia
Stem Cells and Development, 30 (14), 714-724
- PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells
Cell Death & Disease, 12 (1), art. no. 84
- SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System
Stem Cell Reviews and Reports, 17 (5), 1855-1873
- Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes
Toxicology in Vitro, 73, art. no. 105107
2020
- Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
Nature Communications, 11 (1), art. no. 1393
- Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells
Nature Protocols, 15 (11)
2019
- Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
Nature Communications, 10, art. no. 4147
- Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2
Alzheimer's & Dementia, 15 (3), 453-464
- Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA
Cell Reports, 26 (13), 3522-+
2018
- Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration
Alzheimer's & Dementia, 14 (10), 1261-1280
- Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals
PLOS ONE, 13 (12), art. no. e0209097
- PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease
Journal of Neurology, Neurosurgery and Psychiatry, 89, 870-878
- SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells
Stem Cell Reports, 10 (2), art. no. S2213-6711(17)30562-3, 655-672
2017
- HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
Nature Communications, 8 (1), art. no. 861
- Molecular Imaging of Human Embryonic Stem Cells Stably Expressing Human PET Reporter Genes After Zinc Finger Nuclease–Mediated Genome Editing
Journal of Nuclear Medicine, 58 (10), 1659-1665
2016
- Altered neuronal network and rescue in a human MECP2 duplication model
Molecular Psychiatry, 21 (2), 178-88
- Rapid and Efficient Generation of Recombinant Human Pluripotent Stem Cells by Recombinase-mediated Cassette Exchange in the AAVS1 Locus
Journal of Visualized Experiments, (117), art. no. e54718
2014
- FANCA knockout in human embryonic stem cells causes a severe growth disadvantage
Stem Cell Research, 13 (2), 240-50