CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity

Authors

Guo, W., Wang, H., Tharkeshwar, A.K., Couthouis, J., Braems, E., Masrori, P., Van Schoor, E., Fan, Y., Ahuja, K., Moisse, M., Jacquemyn, M., da Costa, R.F M., Gajjar, M., Balusu, S., Tricot, T., Fumagalli, L., Hersmus, N., Janky, R., Impens, F., Vanden Berghe, P., Ho, R., Thal, D.R., Vandenberghe, R., Hegde, M.L., Chandran, S., De Strooper, B., Daelemans, D., Van Damme, P., Van den Bosch, L., Verfaillie, C.

Journal

Alzheimer's & Dementia, 19 (4), 1245-1259

Published

2023

These studies were carried out at the Stem Cell Institute Leuven (KU Leuven) by scientists who now work at ReWrite. All rights to this research belong to KU Leuven.